FVJ   |  e-ISSN: 2602-4225

Original article | Future Visions Journal 2021, Vol. 5(7) 40-49

New Carbonic Anhydrase Inhibitors: Investigation of The Inhibition Effects of Some Synthesis Products on Human Carbonic Anhydrase-I 

Fatma Yaylacı Karahalil, Nurhan Gümrükçüoğlu & İmdat Aygül

pp. 40 - 49   |  DOI: https://doi.org/10.29329/futvis.2021.404.5   |  Manu. Number: fvj.2021.087

Published online: December 30, 2021  |   Number of Views: 10  |  Number of Download: 126


Abstract

In this study, inhibition of human carbonic anhydrase (h CAI) enzyme was investigated in four different organic synthesis compounds. Two of these compounds are [(4-amino-3-phenyl-5-p-tolyl-4H-1,2,4-triazole) (1 ) and (2,5-diphenyl-1,3,4-oxadiazol) (2)] was previously synthesized by our group, while the other two were newly synthesized [(4-methyl-N-(1-tosyl-1H-1,2,4-triazol-3yl)benzene sulfonamide) (3) and (4-(( 5-) bromo-2-hydroxy benilidene)amino)-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one) (4)]. In this study, carbonic anhydrase enzyme inhibition was examined and inhibition values were measured using the Ki and IC50 values of the enzyme. IC50 values measured by esterase activity were detected in the range of 0.023 to 0.095 mM for h CAI, while compound 4 showed the highest inhibition value. Ki values for h CA I was observed between 0.046 and 0.056 mM, and the highest Ki value was also measured for again compound 4.

Keywords: Enzyme inhibition, Benzene sulfonamide, Triazol, Oxadiazole, Shift base, Carbonic anhydrase


How to Cite this Article?

APA 6th edition
Karahalil, F.Y., Gumrukcuoglu, N. & Aygul, I. (2021). New Carbonic Anhydrase Inhibitors: Investigation of The Inhibition Effects of Some Synthesis Products on Human Carbonic Anhydrase-I  . Future Visions Journal, 5(7), 40-49. doi: 10.29329/futvis.2021.404.5

Harvard
Karahalil, F., Gumrukcuoglu, N. and Aygul, I. (2021). New Carbonic Anhydrase Inhibitors: Investigation of The Inhibition Effects of Some Synthesis Products on Human Carbonic Anhydrase-I  . Future Visions Journal, 5(7), pp. 40-49.

Chicago 16th edition
Karahalil, Fatma Yaylaci, Nurhan Gumrukcuoglu and Imdat Aygul (2021). "New Carbonic Anhydrase Inhibitors: Investigation of The Inhibition Effects of Some Synthesis Products on Human Carbonic Anhydrase-I  ". Future Visions Journal 5 (7):40-49. doi:10.29329/futvis.2021.404.5.