Gelecek Vizyonlar Dergisi - Future Visions Journal
           
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Abstract


Influences of Obesity on Circulating Galanin and C-Reactive Protein Concentrations: Results of a Cross-Sectional Study

Galanin (GAL) is a neuropeptide which that is expressed in a tissue specific manner and has been implicated in adult onset diseases such as obesity and lipid and glucose abnormalities. The objective of this study was to investigate the serum levels of GAL and their relationship with obesity in adults. This cross-sectional study included both men and women (total n=261; n=109 women and n=152 men) who applied to the Sleep Disorder Center of Medicine Faculty of Süleyman Demirel University and Sleep Laboratory of Chest Disease Policlinic of Isparta Gülkent Hospital. According to their body mass index (BMI), subjects were grouped into into four categories: normal body weight (<24.9 kg/m2), overweight (25–29,9 kg/m2), obese group 30–39,9 kg/m2) and morbid obese (? 40 kg/m2). Plasma samples from subjects were assayed for each plasma parameter using commercially available analytic systems. The results of this study include that serum GAL levels showed a significantly positive correlation with body mass index (BMI) in both genders. In morbidly obese individuals, galanin levels were significantly higher when compared to other groups. Serum GAL levels were olso positively correlated with C-reactive protein (CRP). In present study, we found that there is a significant positive correlation of BMI with CRP. Our results indicate that inappropriate plasma concentrations of galanin in obese subjets may be a consequence of their weight status, or could be one of many factors involved in the pathogenesis of obesity. Obesity is associated with elevated levels of CRP. The positive associations of obesity with elevated CRP levels suggest the importance of reducing obesity to prevent elevations in CRP levels.



Keywords
Galanin, Obesity, C-reactive protein, Body mass index



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Duyurular

    YENİ SAYI CİLT:4 SAYI:4 YAYINDA

    Dergimizin yeni sayısı (Cilt:4 Sayı:4) yayınlanmıştır. 

    Açık erişim ve kör hakemlik sistemi ile bilimsel yayın yapan Gelecek Vizyonlar Dergisinin 2020 Aralık sayısı (Cilt:4, Sayı:4) beş makale ile yayınlanmıştır. 2021 Mart sayısı için makale kabulü devam etmektedir.



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